Remote work environments have become the dominant mode of knowledge work due to global digital transformation and the post-pandemic transition to hybrid and distributed models. While remote work offers flexibility, productivity benefits, and efficiency, it also poses significant challenges to workers’ digital well-being, including cognitive overload, burnout, technostress, work–life boundary conflicts, and diminished social connectedness. This research article explores the evolving landscape of digital well-being in remote work contexts and proposes a comprehensive “Remote Work Digital Well-Being Model (RW-DWM).” The model integrates psychological, behavioral, organizational, ergonomic, and technological determinants to guide employers, HR managers, and researchers in designing healthier digital work ecosystems.